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Objective: To investigate the changes of blood routine examination and lymphocyte subsets in patients with coronavirus disease 2019 (COVID-19).
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Objective To analyze the detection rate and clinical value of SARS-CoV-2 nucleic acid in anal swab specimen from the convalescent patients with novel coronavirus infection (COVID-19). Methods SARS-CoV-2 nucleic acid samples were detected in convalescent patients with COVID-19 including sputum, pharyngeal swabs and anal swabs specimens. The nucleic acid positive rates of three types of specimens were analyzed. Meanwhile, the nucleic acid detection rates of sputum and pharyngeal swab specimens were analyzed in patients with the positive nucleic acid of anal swab virus. Results A total of 156 samples were collected from 50 patients with COVID 19. The positive for SARS-CoV-2 nucleic acid was 8 (19.5%) in 41 sputum samples. The positive for SARS-CoV-2 nucleic acid was 6 (10.9%) in 55 throat swab samples. The positive for SARS-CoV-2 nucleic acid was 11 (18.3%) in 60 anal swab specimen. Among the 50 convalescent patients with COVID-19, sputum, pharyngeal swabs and anal swab samples were 8 cases (19.5%), 6 cases (12.0%) and 10 cases (20.0%), respectively. In 10 patients with positive anal swab detection, 9 cases were found negative in the respiratory tract specimens. Conclusion The positive detection rate of SARS-CoV-2 nucleic acid is higher in anal swab specimen than that of laryngeal swabs and sputum specimens of the convalescent patients with COVID-19. When SARS-CoV-2 nucleic acid is negative in respiratory tract specimens, the anal swab specimen should be detected in the recovery period, which can be used as leaving hospital standard or isolation standard.
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Objective: To investigate the diagnostic value of severe risk factors and laboratory indicators of coronavirus disease 2019 (COVID-19) in critically ill patients.
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The role of clinical laboratory data in the differential diagnosis of the severe forms of COVID-19 has not been definitely established. The aim of this study was to look for the warning index in severe COVID-19 patients. We investigated 43 adult patients with COVID-19. The patients were classified into mild group (28 patients) and severe group (15 patients). A comparison of the hematological parameters between the mild and severe groups showed significant differences in interleukin-6 (IL-6), d-dimer (d-D), glucose, thrombin time, fibrinogen, and C-reactive protein (P < .05). The optimal threshold and area under the receiver operator characteristic curve (ROC) of IL-6 were 24.3 and 0.795 µg/L, respectively, while those of d-D were 0.28 and 0.750 µg/L, respectively. The area under the ROC curve of IL-6 combined with d-D was 0.840. The specificity of predicting the severity of COVID-19 during IL-6 and d-D tandem testing was up to 93.3%, while the sensitivity of IL-6 and d-D by parallel test in the severe COVID-19 was 96.4%. IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value.